Cyp24a1酶
http://zgbjyxzz.qkku.net/sell/itemid-189991.shtml WebOct 13, 2024 · Mutations in CYP24A1 (vitamin D 24-hydroxylase) and SLC34A1 (renal phosphate transporter NPT2a) cause autosomal recessive Infantile Hypercalcemia type …
Cyp24a1酶
Did you know?
CYP24A1 is expressed in tissues which are considered targets for vitamin D, including kidney, intestine and bone. Transcription of the CYP24A1 gene is markedly inducible by 1,25-(OH)2D3 binding to the vitamin D receptor. The gene has a strong, positive vitamin D response element in the promoter. Through regulation of CYP24A1 expression, a negative feedback control system is created to limit the effects of 1,25-(OH)2D3. WebAug 2, 2024 · We describe a case harboring a homozygous CYP24A1 mutation with mild loss of function, first presenting with recurrent nephrolithiasis from the age of 22 onward, initially associated with hypercalcemia and low PTH concentrations. Over the years, hyperparathyroidism developed, resulting in more severe hypercalcemia. Also, kidney …
WebApr 4, 2024 · CYP24A1 expression is closely associated with colorectal cancer progression, and it might be a novel prognostic biomarker for CRC. The CYP24A1 SNP rs927650 …
WebCYP24A1, encoding the vitamin D-24-hydroxylase, is of major clinical and physiologic importance, serving to regulate the catabolism of 1,25-(OH) 2 D, the physiologically active vitamin D metabolite. In addition to facilitating catabolism of 1,25-(OH) 2 D, CYP24A1 also enhances the turnover and elimination of 25-OHD, the abundant precursor metabolite … Web細胞色素 P450 24A1（英語：Cytochrome P450 24A1，縮寫CYP24A1）也被稱為維生素D3 24-羥化酶（Vitamin D3 24-hydroxylase，EC 1.14.15.16），是細胞色素P450超家族的一 …
WebOct 16, 2009 · Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism. Cytochrome P450 (CYP) 24A1 catalyzes the side-chain oxidation of the hormonal form of vitamin D. Expression of CYP24A1 is up-regulated to attenuate vitamin D signaling associated with calcium homeostasis and cellular growth processes.
http://img1.bioon.com/doc/showarticle.asp?newsid=112603 sharp electronics wikihttp://img1.bioon.com/doc/showarticle.asp?newsid=112603 sharp electronics financial problemsWeb25-羟维生素D3-24-羟基化酶 (CYP24A1)是使1α,25-二羟基维生素D3 (1α,25 (OH)2D3)和25-羟基维生素D3 (25 (OH)D3)代谢失活的关键酶.活性维生素D (1α,25 (OH)2D3)不仅能够 … sharp electronics printer driversWeb细胞色素 P450 24A1（英語： Cytochrome P450 24A1 ，缩写CYP24A1）也被称为维生素D 3 24-羟化酶（ Vitamin D3 24-hydroxylase ，EC 1.14.15.16），是细胞色素P450超家族 … sharp electronics europeWebJan 1, 2011 · CYP24A1 is a mitochondrial inner-membrane cytochrome P450 enzyme that exhibits multifunctionality: it is able to hydroxylate both the C23 or the C24 side-chain carbons of 25(OH)D or 1,25(OH) 2 D. The physiological relevance of these pathways has been confirmed in mice deficient for the Cyp24a1 gene. Recent work has focused on … sharp electronics irelandWebThe CYP24A1 gene provides instructions for making an enzyme called 24-hydroxylase. This enzyme helps control the amount of active vitamin D available in the body. When active, … pork chops and sauerkraut slow cookerWebJan 14, 2015 · NX_Q07973 - CYP24A1 - 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial - Function. A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the … sharpe lintner mossin capm