Web19 de nov. de 2024 · SUMO-specific Isopeptidases Tuning Cardiac SUMOylation in Health and Disease. Paul W. Hotz, Stefan Müller and Luca Mendler *. Institute of Biochemistry II, Gustav Embden Zentrum, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany. SUMOylation is a transient posttranslational modification with small-ubiquitin … Web8 de jan. de 2016 · Abstract. SUMOylation is a ubiquitin-related transient posttranslational modification pathway catalyzing the conjugation of small ubiquitin-like modifier (SUMO) proteins (SUMO1, SUMO2, and SUMO3) to lysine residues of proteins. SUMOylation targets a wide variety of cellular regulators and thereby affects a multitude of different cellular …
SUMO-specific protease 1 is essential for stabilization of ... - PubMed
Web31 de ago. de 2024 · Regulatory axis of VHL, SENP1, and SUMO-enhancer RSUME is essential for the modulation of HIF activity in response to hypoxia. Hypoxia induces SENP1-mediated deSUMOylation of HIFs, promoting the stabilization and transactivation of both HIF1α and HIF2α by protecting them from VHL-mediated proteasomal degradation [ 44 , … Web30 de out. de 2024 · Post-translational modification by SUMO (small ubiquitin-like modifier) proteins has been shown to regulate a variety of functions of proteins, including protein stability, chromatin organization, transcription, DNA repair, subcellular localization, protein–protein interactions, and protein homeostasis. SENP (sentrin/SUMO-specific … csn summerlin learning center
Frontiers SUMO-specific Isopeptidases Tuning Cardiac …
Web14 de mai. de 2015 · SUMO-1, HIF-1α and VEGF levels in rat pulmonary arteries following exposure to hypoxia. The mRNA levels of SUMO-1, HIF-1α and VEGF in pulmonary arteries from control and hypoxia-treated rats were assessed using in situ hybridization and RT-PCR (). SUMO-1 mRNA levels were extremely low in the control group (), increased by day 3 … Web20 de jun. de 2024 · Interestingly, some HIF hydroxylases can also regulate metabolic processes through mechanisms that are at least in part independent of HIF 101,102,103,104. Fig. 3: HIF-mediated adaptations of ... Web24 de fev. de 2024 · SUMOylation, the conjugation of small ubiquitin-related modifier protein (SUMO) to a target protein, has been considered to play an essential regulatory role in HIF-1α protein stability [10,11,12]. SUMOylation of HIF-1α promotes recruitment of the modified protein to VHL through a PHD-independent mechanism, leading to ubiquitination and … eagle wiktionary