Web5 jan. 2024 · Huntingtin interacting protein K (HYPK) forms a tetrameric complex with the human N-terminal acetyltransferase E (NatE). HYPK exhibits negative cooperative … Web1 jun. 2007 · Huntingtin yeast-two hybrid protein K (HYPK) is an intrinsically unstructured protein ( Raychaudhuri et al. 2008a ). It interacts with exon1 of human huntingtin (Htt) and destabilizes mutant Htt ...
Altered Neuronal Dynamics in the Striatum on the Behavior of Huntingtin …
Web20 nov. 2013 · Huntington’s disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene, impairs information processing in the striatum, which, as part of the basal ganglia, modulates motor output. Growing evidence suggests that huntingtin interacting protein 14 (HIP14) contributes to HD … Web24 sep. 2024 · Selective autophagy of protein aggregates is necessary for maintaining the cellular proteostasis. Several regulatory proteins play critical roles in this process. Here, … cheerleading uniforms custom
Recent advances in the modulation of amyloid protein …
The NatA complex is required for HYPK stability and for reducing polyQ aggregation of HTT ( PubMed: 20154145, PubMed: 29754825, PubMed: 32042062 ). Component of the N-terminal acetyltransferase E (NatE)/HYPK complex at least composed of NAA10, NAA15, NAA50 and HYPK ( PubMed: 32042062 ). Meer weergeven This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the … Meer weergeven Web8 apr. 2024 · Beyond a threshold of polyglutamine repeats huntingtin protein (htt e1) becomes amyloidogenic and the associated toxicity has been linked to the development of Huntington's disease [68]. ... Modulators of Protein–Protein Interactions. Chem. Rev., 114 (9) (2014), pp. 4695-4748. CrossRef View in Scopus Google Scholar [84] WebNX_Q9NX55 - HYPK - Huntingtin-interacting protein K - Function. Component of several N-terminal acetyltransferase complexes (PubMed:20154145, PubMed:29754825, PubMed:32042062). Inhibits the N-terminal acetylation activity of the N-terminal acetyltransferase NAA10-NAA15 complex (also called the NatA complex) … flavour water bottles