WebNov 19, 2024 · Three hyperuricemia models were evaluated under the same gene background. • Only Uox-knockout induced abnormal glycometabolism in company with hyperuricemia. • Serious renal damage happened in Uox-knockout mice because of high uric acid level. • Puerarin reduced uric acid level and thus alleviated the consequential renal … WebOct 26, 2024 · In a PO-induced hyperuricemia mouse model, reduction of serum urate by treatment with the XOD inhibitor N-(9,10-anthraquinone-2-yl-carbonyl), downregulates Glut9 protein expression and upregulates Oat1 and Oat3 protein expression, resulting in decrease in the levels of TNF-α, IL-6, and other inflammatory factors in the serum and kidney of …
Comparison of 3 hyperuricemia mouse models and evaluation of food
WebFeb 24, 2024 · Hyperuricemia (>6.8mg/dL) is the main cause of gout and a risk factor for cardiovascular disease, kidney disease, metabolic syndrome and other diseases ( 3 – 6 ). Under physiological conditions, two thirds of uric acid is excreted from the kidneys and one third is excreted through the intestines ( 7 ). WebMar 1, 2024 · Aim Hyperuricemia is defined by the European Rheumatology Society as a uric acid level greater than 6 mg/dl (60 mg/l or 360 μmol/l). Our goal was to evaluate the hypouricemic effect of nettle. internet in murphy nc
Anti-Hyperuricemic and Nephroprotective Effects of …
WebJan 1, 2024 · Methods: The mouse model of hyperuricemia was established by using C57BL/6 mice and a reported protocol. DNA was extracted from fecal samples collected from C57BL/6 mice. Specific primers for... WebNov 19, 2024 · Comparison of 3 hyperuricemia mouse models and evaluation of food-derived anti-hyperuricemia compound with spontaneous hyperuricemia mouse model … WebNov 21, 2024 · The impact of hyperuricemia on fetal development was investigated using a systemic GLUT9 knockout (G9KO) mouse model. Fetal hyperuricemia caused distinctive renal tissue injuries and, subsequently an impaired neonatal growth pattern. These findings provide strong evidence that hyperuricemia plays a major role in the pathogenesis of … internet in mt pleasant tx