WebAntibodies that detect IRF3 can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry, Flow Cytometry and Peptide array. These antibodies target IRF3 in Human, Mouse, Rat, Non-human primate and Porcine samples. Our IRF3 monoclonal, polyclonal, recombinant monoclonal and recombinant ... WebMar 12, 2015 · IRF3 activation requires phosphorylation, dimerization and nuclear translocation. However, the mechanisms for the termination of IRF3 activation in nucleus are elusive. Here we report the identification of TRIM26 to negatively regulate IFN-β production and antiviral response by targeting nuclear IRF3.
TBK1 recruitment to STING activates both IRF3 and NF-κB that
WebMar 21, 2024 · Entrez Gene Summary for IRF3 Gene. This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an … WebHere we show that STING stimulates IRF3 phosphorylation by the kinase TBK1 in an in vitro reconstitution system. Using this system, we identified a carboxyl terminal region of STING that is both necessary and sufficient to activate TBK1 and stimulate IRF3 phosphorylation. flirtey eagle
TBK1 recruitment to STING activates both IRF3 and NF-κB that ... - PNAS
WebMar 21, 2024 · IRF3 (Interferon Regulatory Factor 3) is a Protein Coding gene. Diseases associated with IRF3 include Encephalopathy, Acute, Infection-Induced 7 and Encephalopathy, Acute, Infection-Induced 10 . Among its related pathways are Cytosolic sensors of pathogen-associated DNA and MyD88 dependent cascade initiated on … WebApr 11, 2024 · Since EhaF-mediated inhibition of TLR4-TRIF-IFN pathway occurs at the level of IRF3 phosphorylation ... Cells were lysed after 1.5 h and IRF3 was immunoprecipitated with anti-IRF3 antibody (1:100 ... WebSep 1, 2024 · Immunoblot analysis of IRF3 with anti-phospho-Ser82 antibody and IRF3 antibody in HEK293 cells untreated or infected with SeV (50 HA units/ml) for 8 hr, ... Phosphorylation on IRF3 could turn on or off its function, corresponding to positive or negative regulation, respectively. The positive and negative regulation phosphorylation, … flirt english technique