WebJun 26, 2024 · Editor—Neuromuscular blocking agents (NMBAs) are one of the leading causes of perioperative hypersensitivity reactions.1,2 Investigation of these reactions typically includes skin testing and measurement of specific immunoglobulin E (sIgE) where available. Different patterns of NMBA cross-reactivity between patients appear to indicate … WebBackground: IgE-mediated anaphylaxis to neuromuscular blocking agents (NMBA), frequent in Norway, was proposed to be caused by exposure to pholcodine (PHO) carrying the allergenic quarternary ammonium ion epitope. Consequently, the PHO-containing drug was withdrawn from the market in March 2007.
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WebThe Scandinavian data on pholcodine (PHO) strongly indicates that there is a biological chain from PHO exposure through IgE-sensitization to IgE-mediated anaphylaxis to … WebNov 20, 2013 · Patient total IgE levels also fell following the withdrawal of pholcodine. Among approximately 24 000 samples tested for total IgE, 25.3% had an IgE level >120 kU l −1 in 2006, prior to the withdrawal of pholcodine. This fell to 21.5% in 2009, 2 years following the withdrawal of pholcodine. theorie shampoo green tea
Measurement of pholcodine-specific IgE in addition to morphine …
WebJan 25, 2013 · Alternatively, it has been suggested that pholcodine may sensitize and booster already sensitized individuals to synthesize IgE antibodies to epitopes like tertiary and quaternary ammonium ions implicated in anaphylaxis from neuromuscular blocking agents (NMBA) ( 3 - 6 ). WebPholcodine stimulates a dramatic increase of IgE in IgE-sensitized individuals. A pilot study It seems as cough syrups containing PHO have a most remarkable IgE boostering effect … WebSep 26, 2014 · IgE measurements: total IgE, IgE specific for pholcodine, quaternary ammoniums (KU/L) NMBA and pholcodine cross-sensitisation by testing skin reactions to … theories group living