WebApr 14, 2024 · For example, multiple receptors are involved in the innate immune response to HSV, including NLRP3, which may be ideal targets for immunomodulation. This article … WebJun 29, 2024 · The proviral integration site for moloney murine leukemia virus 1 (Pim1) is a serine/threonine kinase and able to promote cell proliferation, survival and drug resistance. Overexpression of Pim1 has been observed in many cancer types and is associated with the poor prognosis of breast cancer. However, it remains unclear whether Pim1 kinase is a …
The involvement of NLRP3 inflammasome in herpes …
WebThe NLRP3 inflammasome, which has been linked to human inflammatory diseases, is activated by diverse stimuli. How these stimuli activate NLRP3 is unknown. Here we show that different NLRP3 stimuli lead to disassembly of the trans-Golgi network (TGN). WebFeb 4, 2024 · Many groups have described the role of NOD-, LRR-, and pyrin domain–containing protein 3 (NLRP3) as a sensor for pathogen-derived danger signals by antigen-presenting cells in the innate immune system, however, relatively little is known about the contribution of NLRP3 to tumorigenesis, and its role in modulating tumor … au スマートパス 起動しない
Novel Small-Molecule Inhibitor of NLRP3 Inflammasome Reverses …
WebInterleukin (IL)-18 and IL-1β are potent pro-inflammatory cytokines that contribute to inflammatory conditions such as rheumatoid arthritis and Alzheimer’s disease. They are produced as inactive precursors that are activated by large macromolecular complexes called inflammasomes upon sensing damage or pathogenic signals. NLRP3 … WebNLRP3 activator nigericin caused the processing and release of constitutively expressed IL-18 in an unprimed setting. This was mediated by the canonical NLRP3 inflammasome … WebApr 29, 2024 · NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, endogenous danger signals and … au スマートパス 退会