Sialyl-lewis x
WebApr 15, 2006 · CLA defines a subset of human peripheral helper memory T cells and has long been used as a specific carbohydrate determinant in characterizing skin-homing helper memory T-cell populations. 5 The HECA-452 antibody defining CLA was shown to recognize the sialyl Lewis X (Le x) determinant, which is known as a typical carbohydrate ligand for ... WebWe investigated the expression of a number of mucin core proteins and associated O-linked glycans expressed in pancreatic adenocarcinoma-sialyl Tn (STn), Tn, T antigen, sialyl Lewis A (CA19-9), sialyl Lewis C (SLeC), Lewis X (LeX), and sialyl LeX (SLeX)-during the progression of pancreatic cancer from early stages to metastatic disease.
Sialyl-lewis x
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Sialyl Lewis (sLeX), also known as cluster of differentiation 15s (CD15s) or stage-specific embryonic antigen 1 (SSEA-1), is a tetrasaccharide carbohydrate which is usually attached to O-glycans on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes. It is also the means by which … See more Sialyl-Lewis X is a tetrasaccharide composed of a sialic acid, fucose and an N-acetyllactosamine. Its systematic name is 5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine (Neu5Acα2-3Galβ1 … See more Leukocyte homing Sialyl-Lewis is important in leukocyte tethering and rolling. Leukocytes move through the blood stream and then tether themselves to the … See more The term Lewis in its name comes from the name of a family of people who suffered from a red blood cell incompatibility. The studies done on these individuals' red … See more Leukocyte adhesion deficiency Defective synthesis of the sialyl Lewis antigen results in immunodeficiency (leukocyte adhesion deficiency type 2). Defective synthesis can be caused by the loss of fucosyltransferase, impairing the glycosylation of the … See more • CA19-9 (Sialyl-Lewis A) See more • Chen, G.-Y.; Osada, H.; Santamaria-Babi, L. F.; Kannagi, R. (7 November 2006). "Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes" See more WebAug 15, 1995 · After removal of sialic acids, most of the mucins rich in sialyl-Lewis(a) and sialyl-Lewis(x) oligosaccharides no longer bound to a DEAE-cellulose column at pH 8.0. These results indicate that at least part of the sialyl-Lewis(a) and sialyl-Lewis(x) in SW1990 cells is associated with the MUC1 polypeptide.
WebJun 6, 2024 · The sialyl Lewis X (SLe x) antigen encoded by the FUT7 gene is the ligand of endotheliam-selectin (E-selectin).The combination of SLe x antigen and E-selectin represents an important way for malignant tumor metastasis. In the present study, the effect of the SLe x-binding DNA aptamer on the adhesion and metastasis of hepatocellular … WebKeywords: molecular MRI, contrast agent, E-selectin, Sialyl Lewis X, nasopharyngeal carcinoma, iron oxide. Introduction. Nasopharyngeal carcinoma (NPC) may be considered one of the rarer forms of cancer worldwide, but it has high incidence in particular geographic and ethnic populations. 1,2 For instance, NPC incidence is high in southern China. 3.
WebJan 18, 2024 · Among the best described ligands for the selectins are derivatives of the fucosylated and sialylated tetrasaccharides sialyl Lewis x (sLe x, … WebStructures of sialyl Lewis x (sLe x) and sialyl Lewis a (sLe a). Selectins bind to glycans with a terminal tetrasaccharide structure known as sialyl Lewis x/a. The core of the terminal tetrasaccharide is a disaccharide of galactose linked to N-acetylglucosamine (GlcNAc), either in α1,4 (sLe x) or α1,3 (sLe a) linkage.
WebSialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin). Sialyl-Lewis X …
WebMay 31, 2024 · Background: Lewis antigens such as Sialyl Lewis A (sLeA), Sialyl Lewis X (sLeX), Lewis X (LeX), and Lewis Y (LeY) are a class of carbohydrate molecules that are … sonja busch coburgWebResearchGate sonja christoph schoolismWebThe 100 synthetic glycans featured in the Glycan Array 100 are the most frequently identified structures showing important binding function in the literature. For example, influenza virus binds to a variety of sialosides with a serotype-specific pattern. 7-9 Galectins, which are involved in apoptosis, cell adhesion and T-cell activation ... small low tableWebHigh amounts of sialyl Lewis(a) are present in human adenocarcinomas of the colon, pancreas and stomach. A growing amount of data suggests that this carbohydrate … small low stoolsWebApr 8, 2024 · In addition, sialyl Lewis X and sialyl Lewis a are also known to be the ligands of selectins that are a family of cell-adhesion molecules expressed on endothelial cells, leukocytes and platelets. sonjack kitchen bar facturacionWebJan 22, 2015 · Cell adhesion via selectins also results in signaling that may contribute to integrin activation and the transition of rolling cells to firm arrest. 3,4 The sialofucosylated glycans that bind all 3 selectins include the tetrasaccharide sialyl Lewis-X (sLe X) and related structures. 5,6 Although many cell-surface glycoconjugates express such ... sonja corbetts booksWebSialyl-Lewis x (s-Le x)-bearing species have been selected from plasma with the monoclonal antibody CHO-131.This antibody selects s-Le x antigen at points of branching in which the GlcNAc residue of s-Le x is coupled in a β-(1,6) linkage. 60 At N-linked glycosylation sites, s-Le x is conjugated to the glycan matrix through a -GlcNAc-β-(1,6)-Man- linkage and … small lozenge crossword